Fine-tuning of transcription factor binding
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چکیده
منابع مشابه
Fine-tuning of transcription factor binding
numbers and strengths of microRNA-binding sites in the reporter genes. They observed that microRNAs caused a reduction in noise at low levels of reporter protein expression and an increase in noise at high levels of reporter expression. They used the data to construct a mathematical model of microRNA-regulated gene expression noise. The model and the experiments suggest that reduction of intrin...
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κ-casein is a glycosilated protein in mammalian milk that plays an essential role in the milk micelles. Control of κ-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other milk protein genes. Transcriptional regulation, a first mechanism for controlling the development of organisms, is carried out by transcription facto...
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Fine-tuning criteria are frequently used to place upper limits on the masses of superpartners in supersymmetric extensions of the standard model. However, commonly used prescriptions for quantifying naturalness have some important shortcomings. Motivated by this, we propose new criteria for quantifying fine tuning that can be used to place upper limits on superpartner masses with greater fideli...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2015
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.3297